Hydrolytic degradation and bioactivity of lactide and caprolactone based sponge-like scaffolds loaded with bioactive glass particles

摘要

Bioresorbable highly porous polymer scaffolds play a pivotal role in tissue engineering applications. Ideally, the degradation rate of these scaffolds should match the tissue regeneration rate so that there is a gradual transfer of mechanical loads from the scaffold to the regenerated tissue. In this study the degradation behavior of porous and non-porous poly(L-lactide) (PLLA), poly(e-caprolactone) (PCL) and poly(lactide-co-ε-caprolactone) (PLCL) in phosphate buffered saline (PBS) at 37 ℃ for a period up to 18 weeks was investigated. The calculated degradation rates (K_(Mw)) of the samples studied, from the fastest to the slowest, was: PLCL ＞ PLLA ＞ PCL. On the other hand, the porous structures displayed slower degradation rates with respect to their non-porous counterparts. Finally, the bioactivity of a porous PLLA scaffold filled with 0,15 and 30 vol.% of bioactive glass particles was confirmed by the deposition of an apatite layer on the surface of the material. Even in the scaffold filled with 15 vol.% of bioactive glass particles the precipitation of the apatite layer was observed in 14 days, whereas in the scaffold with 30 vol.% of bioactive glass this layer appeared just 3 days after being submerged in simulated body fluid (SBF).