Wound Healing with PRGF Infiltration in CO2 Laser Lesions of the Tongue: An Animal Study

摘要

Objective: This study was done of the effects of plasma rich in growth factors (PRGF) on the healing of tongue wounds induced by the CO₂ laser. Materials and Methods: A prospective blind study was made of 60 Sprague-Dawley rats divided into two groups after the creation of tongue lesions using the CO₂ laser. Nothing was applied to the resulting wounds in the first group, while PRGF was applied to the 30 wounds in the second group. Wound re-epithelialization and inflammation were measured after 7, 14, and 28d. Results: No significant differences were seen between the two groups in relation to wound re-epithelialization, and the group without PRGF actually showed significantly better resolution of the inflammatory process after 14d (p=0.036). Conclusions: After 28d, the rat tongue wounds produced by the CO₂ laser showed complete healing, independently of PRGF application.