Saturable Absorptive Transport of the Hydrophilic Organic Cation Ranitidine in Caco-2 Cells: Role of pH-Dependent Organic Cation Uptake System and P-Glycoprotein

David L. Bourdet; Dhiren R. Thakker

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Saturable Absorptive Transport of the Hydrophilic Organic Cation Ranitidine in Caco-2 Cells: Role of pH-Dependent Organic Cation Uptake System and P-Glycoprotein

机译：亲水性有机阳离子雷尼替丁在Caco-2细胞中的饱和吸收运输：pH依赖的有机阳离子摄取系统和P-糖蛋白的作用

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摘要

The purpose of this work was to investigate the involvement of carrier-mediated apical (AP) uptake and efflux mechanisms in the absorptive intestinal transport of the hydrophilic cationic drug ranitidine in Caco-2 cells.

机译：这项工作的目的是调查在Caco-2细胞中亲水性阳离子药物雷尼替丁的吸收性肠运输中载体介导的根尖（AP）吸收和外排机制的参与。

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来源
《Pharmaceutical Research》 |2006年第6期|1165-1177|共13页
作者
David L. Bourdet; Dhiren R. Thakker;
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作者单位

Division of Molecular Pharmaceutics School of Pharmacy Kerr Hall CB #7360 The University of North Carolina at Chapel Hill Chapel Hill North Carolina 27599-7360 USA;

Division of Molecular Pharmaceutics School of Pharmacy Kerr Hall CB #7360 The University of North Carolina at Chapel Hill Chapel Hill North Carolina 27599-7360 USA;

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正文语种 eng
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关键词
carrier-mediated transport; intestinal absorption; organic cation transport; P-glycoprotein; ranitidine;

机译：载体介导的运输;肠道吸收;有机阳离子运输;P-糖蛋白;雷尼替丁;

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专利

1. Saturable absorptive transport of the hydrophilic organic cation ranitidine in Caco-2 cells: role of pH-dependent organic cation uptake system and P-glycoprotein. [J] . Bourdet DL, Thakker DR Pharmaceutical research . 2006,第6期

机译：亲水性有机阳离子雷尼替丁在Caco-2细胞中的饱和吸收性转运：pH依赖型有机阳离子摄取系统和P-糖蛋白的作用。
2. Intestinal Absorptive Transport of the Hydrophilic Cation Ranitidine: A Kinetic Modeling Approach to Elucidate the Role of Uptake and Efflux Transporters and Paracellular vs. Transcellular Transport in Caco-2 Cells [J] . David L. Bourdet, Gary M. Pollack, Dhiren R. Thakker Pharmaceutical Research . 2006,第6期

机译：亲水性阳离子雷尼替丁的肠道吸收性运输：动力学模型方法，以阐明摄取和外向转运蛋白的作用以及Caco-2细胞中跨细胞与跨细胞运输的作用。
3. Intestinal absorptive transport of the hydrophilic cation ranitidine: a kinetic modeling approach to elucidate the role of uptake and efflux transporters and paracellular vs. transcellular transport in Caco-2 cells. [J] . Bourdet DL, Pollack GM, Thakker DR Pharmaceutical research . 2006,第6期

机译：亲水性阳离子雷尼替丁的肠道吸收性转运：一种动力学建模方法，阐明了Caco-2细胞中摄取和外排转运蛋白以及细胞旁与跨细胞转运的作用。
4. pH-dependent gaboxadol inhibition of hPAT1-mediated proline uptake in Caco-2 cells [C] . S.U. FrΦlund, M. Larsen, C.U. Nielsen Annual meeting exposition of the Controlled Release Society . 2009

机译：pH依赖性加波沙朵对Caco-2细胞中hPAT1介导的脯氨酸摄取的抑制作用
5. Role of Organics in Short-chain Alkyl Amine Uptake by Ammonium Sulfate-organics Mixed Particles [D] . Chu, Yangxi. 2017

机译：有机物在短链烷基胺吸收中的作用通过硫酸铵 - 有机物混合颗粒
6. Characterization of MPP+ secretion across human intestinal Caco-2 cell monolayers: role of P-glycoprotein and a novel Na+-dependent organic cation transport mechanism [O] . Kelly Bleasby, Seema Chauhan, Colin D A Brown 2000

机译：跨人肠道Caco-2细胞单层MPP +分泌的表征：P糖蛋白的作用和一种新型的Na +依赖性有机阳离子转运机制
7. Photoaffinity Labeling of the Anionic Sites in Caco-2 Cells Mediating Saturable Transport of Hydrophilic Cations Ranitidine and Famotidine [O] . -1

机译：介于饱和阳离子的可饱和阳离子和法替辛的可饱和阳离子的Caco-2细胞阴离子位点的光阴离子位点

Saturable Absorptive Transport of the Hydrophilic Organic Cation Ranitidine in Caco-2 Cells: Role of pH-Dependent Organic Cation Uptake System and P-Glycoprotein

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