A Mechanism-Based Integrated Pharmacokinetic Enzyme Model Describing the Time Course and Magnitude of Phenobarbital-Mediated Enzyme Induction in the Rat

摘要

To characterize the magnitude, time course, and specificity of phenobarbital (PB)-mediated enzyme induction, and further, to develop an integrated pharmacokinetic (PK)-enzyme model describing the changes in the activities of CYP enzymes as well as in the PK of PB.