Design and Synthesis of N 4, N 9-Disubstituted Spermines for Non-viral siRNA Delivery – Structure-Activity Relationship Studies of siFection Efficiency Versus Toxicity

摘要

Purpose To study the effect of sequentially changing the chain length, oxidation level, and charge distribution in N 4,N 9-diacyl and N 4,N 9-dialkyl spermines on siRNA formulation, and then to compare their lipoplex transfection efficiency in cell lines.