Spontaneous Crystalline-to-Amorphous Phase Transformation of Organic or Medicinal Compounds in the Presence of Porous Media, Part 3: Effect of Moisture

Ken K. Qian; Dale E. Wurster; Robin H. Bogner

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Spontaneous Crystalline-to-Amorphous Phase Transformation of Organic or Medicinal Compounds in the Presence of Porous Media, Part 3: Effect of Moisture

机译：多孔介质存在下有机或药用化合物的自发晶态到非晶态相变，第3部分：水分的影响

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Amorphization of crystalline compounds using mesoporous media is a promising technique to improve the solubility and drug release of poorly-soluble compounds. The objective of this paper is to understand the effect of moisture on the capacity and performance of vapor-phase mediated amorphization.

机译：使用介孔介质使晶体化合物非晶化是一种改善难溶性化合物的溶解度和药物释放的有前途的技术。本文的目的是了解水分对气相介导的非晶化能力和性能的影响。

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来源
《Pharmaceutical Research》 |2012年第10期|p.2698-2709|共12页
作者
Ken K. Qian; Dale E. Wurster; Robin H. Bogner;
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作者单位

Department of Pharmaceutical Sciences, School of Pharmacy, The University of Connecticut, 69 North Eagleville Rd, Unit 3092, Storrs, Connecticut, 06269, USA;

Division of Pharmaceutics, College of Pharmacy, The University of Iowa, Iowa City, Iowa, 52242, USA;

Department of Pharmaceutical Sciences, School of Pharmacy, The University of Connecticut, 69 North Eagleville Rd, Unit 3092, Storrs, Connecticut, 06269, USA;

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正文语种 eng
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关键词
amorphization; effect of moisture; mesoporous; phase transformation; porous media; silicon dioxide; solubility; thermodynamics;

机译：非晶化;水分效应;介孔;相变;多孔介质;二氧化硅;溶解度;热力学;

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专利

1. Spontaneous crystalline-to-Amorphous phase transformation of organic or medicinal compounds in the presence of porous media, part 3: Effect of moisture [J] . QianK.K., WursterD.E., BognerR.H. Pharmaceutical research . 2012,第10期

机译：在多孔介质存在下有机或药用化合物的自发晶态至非晶态相变，第3部分：水分的影响
2. Spontaneous crystalline-to-amorphous phase transformation of organic or medicinal compounds in the presence of porous media, part 1: thermodynamics of spontaneous amorphization. [J] . Qian KK, Bogner RH Journal of pharmaceutical sciences. . 2011,第7期

机译：在多孔介质存在下有机或药用化合物的自发晶态至非晶态相变，第1部分：自发非晶化的热力学。
3. Spontaneous crystalline-to-amorphous phase transformation of organic or medicinal compounds in the presence of porous media, part 2: amorphization capacity and mechanisms of interaction. [J] . Qian KK, Suib SL, Bogner RH Journal of pharmaceutical sciences. . 2011,第11期

机译：在多孔介质存在下有机或药物化合物的自发晶态到非晶态相变，第2部分：非晶化能力和相互作用机理。
4. Crystalline-to-Amorphous Phase Transformations As a Key Ingredient to Enhanced Rate Performance and Cycle Life in Mg- and Na-Ion Battery Anodes: Operando x-Ray Scattering Studies [C] . Samuel S. Welborn, Lin Wang, Manni Li, Pacific Rim Meeting on Electrochemical and Solid-State Science . 2020

机译：结晶至无定形的相变，作为提高Mg-和Na离子电池阳极速率和循环寿命的关键成分：Operando X射线散射研究
5. Spontaneous Crystalline-to-Amorphous Phase Transformation of Organic or Medicinal Compounds in the Presence of Porous Media. [D] . Qian, Ken Kangyi. 2011

机译：多孔介质存在下有机或药物化合物的自发结晶至非晶相转变。
6. Field-Induced Crystalline-to-Amorphous Phase Transformation on the Si Nano-Apex and the Achieving of Highly Reliable Si Nano-Cathodes [O] . Yifeng Huang, Zexiang Deng, Weiliang Wang, -1

机译：Si纳米顶点上的场致晶体到非晶相变和高度可靠的Si纳米阴极的实现
7. Macroscopic lattice Boltzmann model for heat and moisture transfer process with phase transformation in unsaturated porous media during freezing process [O] . Song Wenyu, Zhang Yaning, Li Bingxi, 2017

机译：非饱和多孔介质冷冻过程中相变热湿传递过程的宏观格子Boltzmann模型
8. Enhancement of Steam Phase Relative Permeability Due to Phase Transformation Effects in Porous Media [R] . Verma, A., Pruess, K. 1986

机译：多孔介质中相变效应引起的汽相相对渗透率的提高

Spontaneous Crystalline-to-Amorphous Phase Transformation of Organic or Medicinal Compounds in the Presence of Porous Media, Part 3: Effect of Moisture

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