Polymeric Nanoparticles for Increased Oral Bioavailability and Rapid Absorption Using Celecoxib as a Model of a Low-Solubility, High-Permeability Drug

Michael Morgen; Corey Bloom; Ron Beyerinck; Akintunde Bello; Wei Song; Karen Wilkinson; Rick Steenwyk; Sheri Shamblin

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Polymeric Nanoparticles for Increased Oral Bioavailability and Rapid Absorption Using Celecoxib as a Model of a Low-Solubility, High-Permeability Drug

机译：使用塞来昔布作为低溶解度，高通透性药物的模型，可提高口服生物利用度和快速吸收的聚合物纳米颗粒

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摘要

To demonstrate drug/polymer nanoparticles can increase the rate and extent of oral absorption of a low-solubility, high-permeability drug.

机译：为了证明药物/聚合物纳米颗粒可以提高低溶解度，高渗透性药物的口服吸收速率和程度。

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来源
《Pharmaceutical Research》 |2012年第2期|p.427-440|共14页
作者
Michael Morgen; Corey Bloom; Ron Beyerinck; Akintunde Bello; Wei Song; Karen Wilkinson; Rick Steenwyk; Sheri Shamblin;
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作者单位

Bend Research Inc., 64550 Research Road, Bend, Oregon, 97701, USA;

Bend Research Inc., 64550 Research Road, Bend, Oregon, 97701, USA;

Bend Research Inc., 64550 Research Road, Bend, Oregon, 97701, USA;

Clinical Pharmacology, Pfizer Oncology, New York, New York, 10017, USA;

Pharmacokinetics, Dynamics &amp Metabolism, Pfizer Worldwide Research &amp Development, Groton, Connecticut, 06340, USA;

Pharmacokinetics, Dynamics &amp Metabolism, Pfizer Worldwide Research &amp Development, Groton, Connecticut, 06340, USA;

Pharmacokinetics, Dynamics &amp Metabolism, Pfizer Worldwide Research &amp Development, Groton, Connecticut, 06340, USA;

Pharmaceutical Sciences, Pfizer Worldwide Research &amp Development, Groton, Connecticut, 06340, USA;

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原文格式 PDF
正文语种 eng
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关键词
bioavailability; celecoxib; ethyl cellulose; nanoparticles; rapid absorption;

机译：生物利用度;塞来昔布;乙基纤维素;纳米颗粒;快速吸收;

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专利

1. Polymeric nanoparticles for increased oral bioavailability and rapid absorption using celecoxib as a model of a low-solubility, high-permeability drug. [J] . Michael Morgen, Corey Bloom, Ron Beyerinck, Pharmaceutical research . 2012,第2期

机译：使用塞来昔布作为低溶解度，高通透性药物的模型，可提高口服生物利用度和快速吸收的聚合物纳米颗粒。
2. Modeling the Influence of Cyclodextrins on Oral Absorption of Low-Solubility Drugs: I. Model Development [J] . Gamsiz ED, Miller L, Thombre AG, Biotechnology and Bioengineering . 2010,第2期

机译：模拟环糊精对低溶解度药物口服吸收的影响：I。模型开发
3. Tacrolimus is a class II low-solubility high-permeability drug: The effect of P-glycoprotein efflux on regional permeability of tacrolimus in rats. [J] . Tamura S, Ohike A, Ibuki R, Journal of pharmaceutical sciences. . 2002,第3期

机译：他克莫司是II类低溶解度高通透性药物：P-糖蛋白外流对他克莫司的区域通透性的影响。
4. Influence of Particle Size on Bioavailability and Rate of Absorption For Oral Dosage FormsPrepared From Poorly Water Soluble Drugs: A Comparison Between in-silico, in-vitro and invivoPharmacokinetic Data [C] . N. P. Ryde, S. L. McGurk Annual meeting exposition of the Controlled Release Society . 2009

机译：粒度对水溶性差的药物制成的口服剂型的生物利用度和吸收率的影响：计算机，体外和体内药代动力学数据的比较
5. Mechanistic Studies and Modeling of the Impact of Food on Oral Drug Absorption [D] . Rezhdo, Oljora. 2018

机译：食物对口服药物吸收影响的机理研究和建模
6. Polymeric Nanoparticles for Increased Oral Bioavailability and Rapid Absorption Using Celecoxib as a Model of a Low-Solubility High-Permeability Drug [O] . Michael Morgen, Corey Bloom, Ron Beyerinck, -1

机译：使用塞来昔布作为低溶解度高通透性药物的模型可提高口服生物利用度和快速吸收的聚合物纳米颗粒
7. Polymeric Nanoparticles for Increased Oral Bioavailability and Rapid Absorption Using Celecoxib as a Model of a Low-Solubility, High-Permeability Drug [O] . Michael Morgen, Corey Bloom, Ron Beyerinck, 2011

机译：使用塞来昔布作为低溶解度，高通透性药物的模型，可提高口服生物利用度和快速吸收的聚合物纳米颗粒
8. Guidance for Industry: Bioavailability and Bioequivalence Studies for Orally Administered Drug Products - General Considerations. Revision 1 [R] . 2003

机译：工业指南：口服药品的生物利用度和生物等效性研究 - 一般考虑因素。修订版1

Polymeric Nanoparticles for Increased Oral Bioavailability and Rapid Absorption Using Celecoxib as a Model of a Low-Solubility, High-Permeability Drug

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