In- or In(I)-employed diastereoselective Reformatsky-type reactions with ketones: H-1 NMR investigations on the active species

摘要

An efficient In- or In(I)-based stereoselective C-C bond formation is reported; the diastereoselective Reformatsky-type reactions of ketones. The predominant formations of anti isomers, confirmed by the X-ray structure analyses of ester derivatives of respective alcohols gal and 13(a1), conclusively revealed the stereochemistry of the reaction path. H-1 NMR investigations revealed the formation of two types of alpha-metalated transient species from a-halo esters with In or In(I) halides.