Total Synthesis of (-)-SNF4435 C and (+)-SNF4435 D

摘要

A convergent,biomimetic total synthesis of the immunosuppressant polyketides SNF4435 C and D is described.The synthetic pathway features a stereo- and regioselective [3,3]-sigmatropic rearrangement as well as a high-yielding Stille coupling/8.T-6,T electrocyclization cascade.