Lewis Acid Assisted Ring-Closing Metathesis of Chiral Diallylamines:An Efficient Approach to Enantiopure Pyrrolidine Derivatives

摘要

Lewis acid assisted ring-closing olefin metathesis(RCM)of chiral diallylamines,using the second generation RCM ruthenium-based catalyst,leads to enantiopure pyrrolidine derivatives in 79-93% yields under very mild conditions.The scope of the olefin metathesis has been expanded.