Stereoselective synthesis of the hormonally active (25S)-Δ~7-dafachronic acid, (25S)-Δ~4-dafachronic acid, (25S)-dafachronic acid, and (25S)-cholestenoic acid

Rene Martin; Frank Daebritz; Eugeni V. Entchev; Teymuras V. Kurzchalia; Hans-Joachim Knoelker

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Stereoselective synthesis of the hormonally active (25S)-Δ~7-dafachronic acid, (25S)-Δ~4-dafachronic acid, (25S)-dafachronic acid, and (25S)-cholestenoic acid

机译：立体选择性合成荷尔蒙活性的（25S）-Δ〜7-大发酸，（25S）-Δ〜4-大发酸，（25S）-大发酸和（25S）-胆甾烯酸

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We report a stereoselective synthesis of the (25S)-cholestenoic-26-acids which are highly efficient ligands for the hormonal receptor DAF-12 in Caenorhabditis elegans.

机译：我们报告的立体选择性合成的（25S）-胆甾烯酸-26-酸是秀丽隐杆线虫中激素受体DAF-12的高效配体。

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《Organic & biomolecular chemistry》 |2008年第23期|4293-4295|共3页
作者
Rene Martin; Frank Daebritz; Eugeni V. Entchev; Teymuras V. Kurzchalia; Hans-Joachim Knoelker;
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Department Chemie, Technische Universitaet Dresden, Bergstrasse 66, 01069 Dresden, Germany;

Department Chemie, Technische Universitaet Dresden, Bergstrasse 66, 01069 Dresden, Germany;

Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany;

Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany;

Department Chemie, Technische Universitaet Dresden, Bergstrasse 66, 01069 Dresden, Germany;

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机译：立体选择性合成（25R）-大发酸和（25R）-胆烯酸作为秀丽隐杆线虫DAF-12受体的潜在配体
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Stereoselective synthesis of the hormonally active (25S)-Δ~7-dafachronic acid, (25S)-Δ~4-dafachronic acid, (25S)-dafachronic acid, and (25S)-cholestenoic acid

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