Palladium-catalyzed decarboxylative cross-coupling reaction of cinnamic acid with aryl iodide

摘要

A highly effective decarboxylative cross-coupling reaction of cinnamic acid with aryl iodide catalyzed by the combination of palladium chloride and CyJohnPhos in the presence of Ag_2CO_3 as an additive is described. The desired carbon-carbon bond formation proceeds efficiently with good functional-group tolerance.rnRecently, the decarboxylative cross-coupling reaction has attracted much attention since it opens a new avenue for carbon-carbon formation. As highlighted by Baudoin, this method has several advantages over the conventional transition metal-catalyzed cross-coupling reactions and the direct arylation through C-H activation, concerning the regioselectivity as well as atom and step economy issues.