Development of strong Bronsted base catalysis: catalytic direct-type Mannich reactions of non-activated esters via a product-base mechanism

摘要

A catalytic Mannich reaction of a simple ester with no acti-vating functionality at the a-position via a product-base mechanism was reported. The desired Mannich adducts were obtained in high yields using a catalytic amount of KH. This is a rare example of a Bronsted base-catalyzed Mannich reaction of unactivated esters as substrates.