Lewis acid-mediated radical cyclization: stereocontrol in cascade radical addition-cyclization-trapping reactions

摘要

An efficient approach for achieving radical cyclizations by using hydroxamate ester as a coordination tether with Lewis acid was studied. The chiral Lewis acid-mediated cascade radical addition-cyclization-trapping reaction proceeded smoothly with good enantio- and diastereoselectivities, providing various chiral y-lactams.