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首页> 外文期刊>Organic & biomolecular chemistry >Highly selective fluorescence off-on probes for biothiols and imaging in live cells
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Highly selective fluorescence off-on probes for biothiols and imaging in live cells

机译：用于生物硫醇和活细胞成像的高选择性荧光关闭探针

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摘要

Three sulfonyl benzothiazole-based fluorescent probes (RSHP1, RSHP2, and RSHP3) for the detection of biothiols (cysteine, homocysteine, and glutathione) are developed based on thiol-mediated nucleophilic aromatic substitutions. The probes exhibited good selectivity and sensitivity toward biothiols over other analytes. The probes were successfully applied for visualizing endogenous thiols in living cells.
机译：基于硫醇介导的亲核芳香族取代，开发了三种用于检测生物硫醇（半胱氨酸，高半胱氨酸和谷胱甘肽）的基于磺酰基苯并噻唑的荧光探针（RSHP1，RSHP2和RSHP3）。与其他分析物相比，该探针对生物硫醇具有良好的选择性和敏感性。该探针已成功应用于可视化活细胞中的内源硫醇。

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  • 来源
    《Organic & biomolecular chemistry 》 |2014年第35期| 6837-6841| 共5页
  • 作者

    Di Zhang; Wei Chen; Jianming Kang; Yong Ye; Yufen Zhao; Ming Xian;

  • 作者单位

    College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450052, China,Department of Chemistry, Washington State University, Pullman, WA 99164, USA;

    Department of Chemistry, Washington State University, Pullman, WA 99164, USA;

    Department of Chemistry, Washington State University, Pullman, WA 99164, USA;

    College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450052, China;

    College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450052, China;

    Department of Chemistry, Washington State University, Pullman, WA 99164, USA;

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