DNA wormholes could lead to the $100 genome sequence

摘要

Drawing individual strands of DNA through nanoscopic pores in a chip could do in a matter of minutes what the human genome project took more than a decade to achieve - sequence an entire human genome.rnKnown as solid state nanopore sequencing, the technique identifies DNA base pairs by measuring their electrical properties as they pass through a tiny hole - relying on the fact that DNA nucleotides each possess distinct electrical signatures. It marks a radical move away from the traditional biochemical and optical approaches to genome sequencing, and according to IBM and Roche Applied Science, who are teaming up to develop the technology, it could slash the cost of sequencing a genome from over $10,000 to as little as $100.