Influence of dendritic topology on firing patterns in model neurons

摘要

Neuronal electrophysiology is influenced by both channel distribution and morphology. Distinguishing two sources of morphological variability-metrics and topology-we show that Model neurons sharing the same channel densities and anatomical size can derive functional Differentiation from their dendritic topology. Firing frequencies in these metrically reduced Neurons show a strong correlation with both mean path length and total electronic trans- Formed size of the dendritic tree. This dependency of spiking behavior is robust to different Modes of stimulation, different tapering powers, and the absence of active dendritic chan- nels.