Penetrating the brain tumor space with DNA damage response inhibitors

Bindra Ranjit S.

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Penetrating the brain tumor space with DNA damage response inhibitors

机译：用DNA损伤反应抑制剂穿透脑肿瘤空间

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来源
《Neuro-Oncology》 |2020年第12期|1718-1720|共3页
作者
Bindra Ranjit S.;
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作者单位

Yale Sch Med Dept Therapeut Radiol New Haven CT USA;

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正文语种 eng
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入库时间 2022-08-18 23:31:58

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1. Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage. [J] . Ameya Paranjpe, Ruiwen Zhang, Francis Ali-Osman, Carcinogenesis . 2014,第3期

机译：双硫仑是脑肿瘤细胞和小鼠脑中人O6-甲基鸟嘌呤-DNA甲基转移酶（MGMT）的直接有效抑制剂，并显着增加了烷基化DNA的损伤。
2. Patterns of DNA damage response in intracranial germ cell tumors versus glioblastomas reflect cell of origin rather than brain environment: Implications for the anti-tumor barrier concept and treatment [J] . Jirina Bartkova, Christina E. Hoei-Hansen, Katerina Krizova, Molecular oncology. . 2014,第8期

机译：颅内生殖细胞肿瘤与胶质母细胞瘤中DNA损伤反应的模式反映了起源细胞而不是脑环境：抗肿瘤屏障概念和治疗的含义
3. Biodegradable brain-penetrating DNA nanocomplexes and their use to treat malignant brain tumors [J] . Panagiotis Mastorakos, Clark Zhang, Eric Song, Journal of Controlled Release: Official Journal of the Controlled Release Society . 2017,第期

机译：可生物降解的脑穿透DNA纳米复合物及其用于治疗恶性脑肿瘤的用途
4. Diverse DNA Damage Response Mechanisms in Cancer: From Tumor Suppression to Therapeutic Targets [C] . Conference of the American College of Veterinary Internal Medicine (ACVIM) . 2017

机译：癌症中不同的DNA损伤反应机制：从肿瘤抑制对治疗目标
5. Post-translational modification of the ribonucleotide reductase inhibitor, Sml1, in response to DNA damage. [D] . Andreson, Bethany L. 2009

机译：响应DNA损伤，核糖核苷酸还原酶抑制剂Sml1的翻译后修饰。
6. 64. AN ENT2-DEPENDENT CELL-PENETRATING AND DNA-DAMAGING LUPUS AUTOANTIBODY CROSSES THE BLOOD-BRAIN BARRIER TO TARGET BRAIN TUMORS [O] . Zahra Rattray, Gang Deng, Shenqi Zhang, 2020

机译：64.依赖于Ent2依赖性细胞穿透和DNA损伤的狼疮Autoantibody通过血脑屏障来靶向脑肿瘤
7. 64. AN ENT2-DEPENDENT, CELL-PENETRATING, AND DNA-DAMAGING LUPUS AUTOANTIBODY CROSSES THE BLOOD-BRAIN BARRIER TO TARGET BRAIN TUMORS [O] . Zahra Rattray, Gang Deng, Shenqi Zhang, 2020

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Penetrating the brain tumor space with DNA damage response inhibitors

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