CSF-1R inhibition alters macrophage polarization and blocks glioma progression

摘要

There has been accumulating interest in the role of tumor associated inflammatory cells in cancer initiation, progression and response to therapy. The subpopulation of interest have been tumor- associated macrophages and in the case of Glioblastoma Multiforme macrophages and microglia (TAMs). TAMs demonstrate a high degree of plasticity in response to the tumor micro-environment and can assume a wide range of roles, capable of both promoting and opposing tumor development. It is recognized that TAMs depend on colony stimulating factor-1 (CSF-1) for differentiation and survival.