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Phase II trial of pegylated interferon alfa-2b in young patients with neurofibromatosis type 1 and unresectable plexiform neurofibromas

机译:聚乙二醇化干扰素α-2b在年轻的1型神经纤维瘤病和无法切除的丛状神经纤维瘤患者中进行的II期临床试验

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摘要

Background. There is no proven medical therapy for plexiform neurofibromas (PNs). We undertook a phase II trial of pegylated interferon (PI) to evaluate response and time to progression (TTP).
机译:背景。对于丛状神经纤维瘤(PNs),尚无行之有效的药物疗法。我们进行了聚乙二醇化干扰素(PI)的II期试验,以评估反应和进展时间(TTP)。

著录项

  • 来源
    《Neuro-Oncology》 |2017年第2期|289-297|共9页
  • 作者单位

    Childrens Hosp Pittsburgh, 4401 Penn Ave Pittsburgh, Penn Ave Pittsburgh, PA 4401 USA|AstraZeneca One Medimmune Way, Gaithersburg, MD USA;

    Natl Canc Inst, Biostatist & Data Management Sect SS, Pediat Oncol Branch, Ctr Canc Res, Bldg 10, Bethesda, MD 20892 USA;

    Ann & Robert Lurie Childrens Hosp, 225 Chicago Ave, Chicago, IL 60611 USA;

    Dana Farber Boston Childrens Canc & Blood Disorde, 450 Brookline Ave, Boston, MA 02215 USA;

    AstraZeneca One Medimmune Way, Gaithersburg, MD USA;

    AstraZeneca One Medimmune Way, Gaithersburg, MD USA;

    Childrens Hosp Pittsburgh, 4401 Penn Ave Pittsburgh, Penn Ave Pittsburgh, PA 4401 USA;

    Natl Canc Inst, Biostatist & Data Management Sect SS, Pediat Oncol Branch, Ctr Canc Res, Bldg 10, Bethesda, MD 20892 USA;

    AstraZeneca One Medimmune Way, Gaithersburg, MD USA;

    Dana Farber Boston Childrens Canc & Blood Disorde, 450 Brookline Ave, Boston, MA 02215 USA|Childrens Hosp Chicago, Ann & Robert H Lurie, 225 E Chicago Ave.,Box 30, Chicago, IL USA;

    Dana Farber Boston Childrens Canc & Blood Disorde, 450 Brookline Ave, Boston, MA 02215 USA;

    Natl Canc Inst, Biostatist & Data Management Sect SS, Pediat Oncol Branch, Ctr Canc Res, Bldg 10, Bethesda, MD 20892 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    clinical trials; interferon; neurofibromatosis type 1; plexiform neurofibromas; pediatrics;

    机译:临床试验;干扰素;1型神经纤维瘤;丛状神经纤维瘤;儿科;

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