Stable graft function after reduction of calcineurin inhibitor dosage in paediatric kidney transplant patients

摘要

Background. Chronic calcineurin inhibitor (CNI) toxicity contributes to the development and progression of chronic allograft nephropathy (CAN), which is still the major cause of transplant dysfunction and graft loss. Reduction in dosage of CNI may delay the development of CAN, leading to longer graft survival.