Diazoxide attenuates hypothermic preservation-induced renal injury via down-regulation of CHOP and caspase-12

摘要

Background. Successful clinical organ preservations are a prerequisite for organ transplantation. Diazoxide (DE), which shows a concentration-dependent selectivity for mitoK+--ATP over plasma membrane K+--ATP, displays protective effects during organ preservation. The current study investigated possible protective effects of DE on rat kidneys injured by hypothermic preservation.