Parathyroid hormone-related protein induces hypertrophy in podocytes via TGF-β1 and p27Kip1: implications for diabetic nephropathy

Ricardo J. Bosch

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Parathyroid hormone-related protein induces hypertrophy in podocytes via TGF-β1 and p27Kip1: implications for diabetic nephropathy

机译：甲状旁腺激素相关蛋白通过TGF-β1和p27Kip1诱导足细胞肥大：对糖尿病肾病的影响

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Background. Hypertrophy of podocytes is characteristic in diabetic nephropathy (DN). Previously, we observed the upregulation of parathyroid hormone-related protein (PTHrP) and its receptor PTH1R, in experimental DN, associated with renal hypertrophy. Herein, we test the hypothesis that PTHrP participates in the mechanism of high glucose (HG)-induced podocyte hypertrophy.

机译：背景。足细胞肥大是糖尿病肾病（DN）的特征。先前，我们观察到实验性DN中甲状旁腺激素相关蛋白（PTHrP）及其受体PTH1R的上调与肾脏肥大有关。在本文中，我们测试了PTHrP参与高葡萄糖（HG）诱导的足细胞肥大机制的假设。

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《Nephrology Dialysis Transplantation》 |2010年第8期|p.2447-2457|共11页
作者
Ricardo J. Bosch;
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University of Alcalá,;

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1. Parathyroid hormone-related protein induces hypertrophy in podocytes via TGF-beta(1) and p27(Kip1): implications for diabetic nephropathy. [J] . Montserrat Romero, Arantxa Ortega, Adriana Izquierdo, Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association . 2010,第8期

机译：甲状旁腺激素相关蛋白通过TGF-beta（1）和p27（Kip1）诱导足细胞肥大：对糖尿病肾病的影响。
2. Novel Role of Parathyroid Hormone-Related Protein in the Pathophysiology of the Diabetic Kidney: Evidence from Experimental and Human Diabetic Nephropathy [J] . Romero Montserrat, Ortega Arantxa, Olea Nuria, International Journal of Experimental Diabetes Research: Experimental Diabesity Research . 2013,第1期

机译：甲状旁腺激素相关蛋白在糖尿病肾脏病理生理中的新作用：来自实验性和人类糖尿病性肾病的证据
3. Novel Role of Parathyroid Hormone-Related Protein in the Pathophysiology of the Diabetic Kidney: Evidence from Experimental and Human Diabetic Nephropathy [J] . Romero Montserrat, Ortega Arantxa, Olea Nuria, International Journal of Experimental Diabetes Research: Experimental Diabesity Research . 2013,第1期

机译：甲状旁腺激素相关蛋白在糖尿病肾脏病理生理中的新作用：来自实验性和人类糖尿病性肾病的证据
4. Highly potent analogs of human parathyroid hormone and human parathyroid hormone-related protein [C] . Jesse Z.Dong, Yeelana Shen, Michael Culler, the International Peptide Symposium . 2001

机译：人甲状旁腺激素和人甲状旁腺激素相关蛋白的高效类似物
5. Urinary gene expression as a marker of glomerular podocyte injury and disturbance of renin-angiotensin system in patients with diabetic nephropathy. [D] . Wang, Gang. 2008

机译：尿基因表达作为糖尿病肾病患者肾小球足细胞损伤和肾素-血管紧张素系统紊乱的标志物。
6. Novel Role of Parathyroid Hormone-Related Protein in the Pathophysiology of the Diabetic Kidney: Evidence from Experimental and Human Diabetic Nephropathy [O] . Montserrat Romero, Arantxa Ortega, Nuria Olea, 2013

机译：甲状旁腺激素相关蛋白在糖尿病肾脏病理生理中的新作用：来自实验性和人类糖尿病性肾病的证据
7. The parathyroid hormone-related protein system and diabetic nephropathy outcome in streptozotocin-induced diabetes [O] . Izquierdo A., López-Luna P., Ortega A., 2006

机译：链脲佐菌素诱发的糖尿病中甲状旁腺激素相关蛋白系统和糖尿病肾病的预后

Parathyroid hormone-related protein induces hypertrophy in podocytes via TGF-β1 and p27Kip1: implications for diabetic nephropathy

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