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Electrical conduction through DNA molecules

机译:通过DNA分子的导电

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摘要

The question of whether DNA is able to transport electrons has attracted much interest, particularly as this ability may play a role as a repair mechanism after radiation damage to the DNA helix. Experiments addressing DNA conductivity have involved a large number of DNA strands doped with intercalated donor ana acceptor molecules, and the conductivity has been assessed from electron transfer rates as a function of the distance between the donor and acceptor sites. But the experimental results remain contradictory, as do theoretical predictions. Here we report direct measurements of electrical current as a function of the potential applied across a few DNA molecules associated into single ropes at least 600 nm long, which indicate efficient conduction through the ropes. We find that the resistivity values derived from these measurements are comparable to those of conducting polymers, and indicate that DNA transports electrical current as efficiently as a good semiconductor. This property, and the fact that DNA molecules of specific composition ranging in length from just a few nucleotides to chains several tens of micrometres long can be routinely prepared, makes DNA ideally suited for the construction of mesoscopic electronic devices.
机译:DNA是否能够传输电子的问题引起了人们的极大兴趣,特别是因为这种能力可能在辐射损伤DNA螺旋后起修复机制的作用。解决DNA电导率的实验涉及大量掺杂有插入的供体和受体分子的DNA链,并且已根据电子传递速率评估了电导率,该速度是供体和受体位点之间距离的函数。但是实验结果仍然与理论预测相矛盾。在这里,我们报告了电流的直接测量,该电流是跨至少600 nm长的单根绳索关联的几个DNA分子上施加的电势的函数,这表明通过绳索的有效传导。我们发现,从这些测量值得出的电阻率值可与导电聚合物的电阻率值相比较,并且表明DNA可以像好的半导体一样有效地传输电流。可以常规制备这种性质,并且可以常规地制备特定组成的DNA分子,其长度范围从几个核苷酸到几十个微米长的链,这一事实使DNA非常适合构造介观电子设备。

著录项

  • 来源
    《Nature》 |1999年第6726期|p.407-410|共4页
  • 作者单位
  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 自然科学总论;
  • 关键词

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