Huntington's disease is a heritable disorder that affects more than 1 in 10,000 people. Its associated neurological symptoms are severe, and there is no therapy to halt or slow its progress. To understand its pathology, and with the ultimate hope of finding a treatment, researchers have generated several experimental models of this disease1, in organisms such as flies and rodents. Although these models have led to tremendous progress in understanding the pathogenic mechanisms of Huntington's disease, none of them can replicate all the behavioural changes seen in the human disease or the changes that occur at the tissue level. The need for a primate model of the disease is thus clear.
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