Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer's disease

摘要

Senile plaques accumulate over the course of decades in the brains of patients with Alzheimer's disease. A fundamental tenet of the amyloid hypothesis of Alzheimer's disease is that the deposition of amyloid-β precedes and induces the neuronal abnormalities that underlie dementia.