Enzymes of the TET family convert 5-methylcytosine (5-mC) to 5-hydroxy-methylcytosine (5-hmC) in, DNA. Mutations in the gene encoding TET2 are common in myeloid malignancies. These disease-associated mutations are now shown to compromise TET2 catalytic activity: bone-marrow samples from patients with TET2 mutations have low levels of 5-hmC in genomic DNA, and TET2 is required for normal haematopoietic differentiation.
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