FROM TOOLS TO THERAPIES

摘要

It's not only clinical researchers who are looking for the best ways to get synthetic oligonucleotides into cells in living mammals. If the delivery problem were solved, says Phillip Sharp, who studies RNA interference (RNAi) at the Massachusetts Institute of Technology (MIT) in Cambridge, the ability to use animals to study physiology and disease would expand dramatically. "You can't make a knockout dog, but you could probe genetic function with RNAi."