The VI/V2 variable region of the gpl20 envelope glycoprotein of HI V-1, with its extraordinary sequence diversity and N-linked glycosylation, exemplifies the ability of the virus to evade antibody recognition. It has also resisted structural determination. Now Peter Kwong and colleagues have determined the structure of gp 120 V1 /V2 from two strains of the virus in complex with PG9, an antibody that can neutralize most strains of HIV-1.
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