People's immune response to an influenza vaccine can be predicted after vaccination from gene-expression signatures. Bali Pulendran at Emory University in Atlanta, Georgia, and his colleagues measured immune responses and gene-expression changes in the white blood cells of 56 volunteers who received the inactivated vaccine against seasonal flu. Expression levels of 42 sets of 3 or 4 genes were used to predict flu-specific antibody response to the inactivated vaccine. For example, levels of the gene CaMKIV were inversely correlated with the antibody responses.
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