Anti-inflammatory action by DC-SIGN

摘要

High-dose intravenous immunoglobulin is used to suppress autoantibody-mediated inflammation in various clinical settings. A study in 'humanized' mice shows that the lectin receptor DC-SIGN initiates this response through an anti-inflammatory cascade induced by a natural ligand — sialylated IgG crystallized fragment — the levels of which are regulated by inflammation.