Research

摘要

Childhood herpes simplex encephalitis (HSE) is a rare but severe disease in which the usually innocuous herpes simplex virus 1 infects the central nervous system. Fabien Lafaille et al. report the development of an in vitro model for HSE. They derived induced pluripotent stem cells (iPSCs) from patients deficient in TLR3 and UNC-93B. Neurons and immature oligodendrocytes from these iPSCs are susceptible to infection by the virus and fail to induce the normal innate immune response.