In the 1930s, the pioneering geneticist J. B. S. Haldane noticed a peculiar inheritance pattern in families with long histories of haemophilia. The faulty mutation responsible for the blood-clotting disorder tended to arise on the X chromosomes that fathers passed to their daughters, rather than on those that mothers passed down. Haldane subsequently proposed1 that children inherit more mutations from their fathers than their mothers, although he acknowledged that "it is difficult to see how this could be proved or disproved for many years to come".
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机译：在1930年代，具有开创性的遗传学家J. B. S. Haldane注意到血友病历史悠久的家庭具有独特的遗传模式。造成血液凝固障碍的错误突变往往发生在父亲传给女儿的X染色体上，而不是母亲传给女儿的X染色体上。霍尔丹随后提出[1]，尽管他承认“很难在以后的许多年中证明或证明这一点，但他的父亲比母亲继承了更多的突变”。
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