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The genomic basis of adaptive evolution in threespine sticklebacks

机译:三脊背棘适应性进化的基因组学基础

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摘要

Marine stickleback fish have colonized and adapted to thousands of streams and lakes formed since the last ice age, providing an exceptional opportunity to characterize genomic mechanisms underlying repeated ecological adaptation in nature. Here we develop a high-quality reference genome assembly for threespine sticklebacks. By sequencing the genomes of twenty additional individuals from a global set of marine and freshwater populations, we identify a genome-wide set of loci that are consistently associated with marine-freshwater divergence. Our results indicate that reuse of globally shared standing genetic variation, including chromosomal inversions, has an important role in repeated evolution of distinct marine and freshwater sticklebacks, and in the maintenance of divergent ecotypes during early stages of reproductive isolation. Both coding and regulatory changes occur in the set of loci underlying marine-freshwater evolution, but regulatory changes appear to predominate in this well known example of repeated adaptive evolution in nature.
机译:自从上个冰河时代以来,海洋棘背鱼已经定居并适应了成千上万的溪流和湖泊,为描述自然界中反复生态适应的基因组机制提供了难得的机会。在这里,我们为三脊椎棘背stick开发了高质量的参考基因组组件。通过对来自全球海洋和淡水种群的另外20个人的基因组进行测序,我们确定了与海洋淡水发散一致相关的全基因组基因座。我们的结果表明,全球共有的常规遗传变异(包括染色体倒置)的再利用在不同海洋和淡水stick的反复进化中以及在生殖隔离的早期阶段维持不同生态型中具有重要作用。编码变化和调节变化都发生在海洋淡水演化的潜在位点集中,但是在这个众所周知的自然界中反复适应性进化的例子中,调节变化似乎占主导地位。

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  • 来源
    《Nature》 |2012年第7392期|p.55-61|共7页
  • 作者单位

    Department of Developmental Biology, Beckman Center B300, Stanford University School of Medicine, Stanford California 94305, USA;

    Broad Institute of MIT and Harvard, 7 Cambridge Center,Cambridge Massachusetts 02142, USA,Science for Life Laboratory Uppsala, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala 751 23, Sweden;

    Department of Developmental Biology, Beckman Center B300, Stanford University School of Medicine, Stanford California 94305, USA,Max Planck Institute for Evolutionary Biology, August-Thienemann-Str. 2, Plon 24306, Germany;

    Broad Institute of MIT and Harvard, 7 Cambridge Center,Cambridge Massachusetts 02142, USA;

    Broad Institute of MIT and Harvard, 7 Cambridge Center,Cambridge Massachusetts 02142, USA,Children's Hospital Boston, Genetic Diagnostic Lab, 300 Longwood Avenue, Boston. Massachusetts 02115, USA;

    Broad Institute of MIT and Harvard, 7 Cambridge Center,Cambridge Massachusetts 02142, USA;

    Broad Institute of MIT and Harvard, 7 Cambridge Center,Cambridge Massachusetts 02142, USA;

    Broad Institute of MIT and Harvard, 7 Cambridge Center,Cambridge Massachusetts 02142, USA,Bioinformatics Core, Zuckerman Research Center, New York, New York 10065, USA;

    Broad Institute of MIT and Harvard, 7 Cambridge Center,Cambridge Massachusetts 02142, USA;

    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK;

    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK;

    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK;

    HudsonA!pha Institute for Biotechnology,601 Genome Way, Huntsville, Alabama 35806, USA;

    HudsonA!pha Institute for Biotechnology,601 Genome Way, Huntsville, Alabama 35806, USA;

    HudsonA!pha Institute for Biotechnology,601 Genome Way, Huntsville, Alabama 35806, USA;

    HudsonA!pha Institute for Biotechnology,601 Genome Way, Huntsville, Alabama 35806, USA;

    Department of Developmental Biology, Beckman Center B300, Stanford University School of Medicine, Stanford California 94305, USA,Department of Molecular & Cell Biology, 142 LSA 3200, University of California, Berkeley, California 94720, USA;

    Department of Developmental Biology, Beckman Center B300, Stanford University School of Medicine, Stanford California 94305, USA;

    Department of Developmental Biology, Beckman Center B300, Stanford University School of Medicine, Stanford California 94305, USA;

    Department of Developmental Biology, Beckman Center B300, Stanford University School of Medicine, Stanford California 94305, USA;

    Department of Developmental Biology, Beckman Center B300, Stanford University School of Medicine, Stanford California 94305, USA;

    Department of Developmental Biology, Beckman Center B300, Stanford University School of Medicine, Stanford California 94305, USA;

    Department of Developmental Biology, Beckman Center B300, Stanford University School of Medicine, Stanford California 94305, USA;

    Department of Molecular Genetics, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle Washington 98101, USA;

    Broad Institute of MIT and Harvard, 7 Cambridge Center,Cambridge Massachusetts 02142, USA;

    Broad Institute of MIT and Harvard, 7 Cambridge Center,Cambridge Massachusetts 02142, USA;

    Broad Institute of MIT and Harvard, 7 Cambridge Center,Cambridge Massachusetts 02142, USA,Science for Life Laboratory Uppsala, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala 751 23, Sweden;

    Department of Developmental Biology, Beckman Center B300, Stanford University School of Medicine, Stanford California 94305, USA,Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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  • 入库时间 2022-08-18 02:54:03

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