The TLR4 antagonist Eritoran protects mice from lethal influenza infection

摘要

随着流感病毒的继续演化以及它对现有抗病毒rn疗法抵抗力的不断蔓延，我们迫切需要新的抗rn流感疗法。以前的研究工作表明，TLR4信号rn作用介导小鼠由流感诱导的急性肺损伤、细胞rn因子生成和系统效应。现在，Stefarlie Voqelrn及其同事报告，Eritoran(一种合成TLR4拮抗rn剂)在被流感病毒感染之后长达6天施用，可保rn护小鼠不会死掉。现有抗病毒药物必须在感染rn后3天内施用才会有效。%There is a pressing need to develop alternatives to annual influenza vaccines and antiviral agents licensed for mitigating influenza infection. Previous studies reported that acute lung injury caused by chemical or microbial insults is secondary to the generation of host-derived, oxidized phospholipid that potently stimulates Toll-like receptor 4 (LR4)- dependent inflammation1. Subsequently, we reported that Tlr4-/-mice are highly refractory to influenza-induced lethality2, and proposed that therapeutic antagonism of TLR4 signalling would protect against influenza-induced acute lung injury.