Microbe-tolerant T_(reg) cells

摘要

The identity of the intestinal regulatory T (T_(reg)) cells that control autoimmune diseases and immune responses to commensal microbes remains ill defined. Anna Cebula et al. now use high-throughput sequencing of T-cell receptors to show that the predominant T_(reg) cells in all lymphoid and intestinal organs, including the colon, are derived from the thymus. This challenges the view that induced rather than thymic T_(reg) cells are mainly responsible for the control of intestinal inflammation.