Cancer Screening for tumour evolution

摘要

This proof-of-principle study shows that by sequencing cancer exomes from patient plasma, it is possible to track genomic evolution of metastatic cancers and acquisition of resistance during therapy. In six patients with advanced breast, lung and ovarian cancer, sequences were derived from plasma samples taken during multiple courses of treatment. Mutations associated with resistance to drugs including cisplatin, tamoxifen and gefitinib were identified. Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA