Serotonin 5-HT_3 receptor structure

摘要

When the neurotransmitter serotonin binds to the 5-HT_3 receptor, the channel opens, generating an excitatory-response. This study reports the first X-ray crystal structure of the mouse serotonin 5-HT_3 receptor. The overall structure is similar to those of other Cys-loop receptors, although the authors were able to 'see' electron density for part of the cytoplasmic domain. This region is important for trafficking, synaptic localization and modulation by cytoplasmic proteins, but has not been visible in previous structures. Antagonists of the 5-HT_3 receptor are used as anti-emetics or to treat irritable bowel syndrome, so the hope is that this work could aid the design of new therapeutic agents.