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Protective mucosal immunity mediated by epithelial CD1d and IL-10

机译：上皮CD1d和IL-10介导的保护性粘膜免疫

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摘要

The mechanisms by which mucosal homeostasis is maintained are of central importance to inflammatory bowel disease. Critical to these processes is the intestinal epithelial cell (IEC), which regulates immune responses at the interface between the commensal micro-biota and the host. CD1d presents self and microbial lipid antigens to natural killer T (NKT) cells, which are involved in the pathogenesis of colitis in animal models and human inflammatory bowel disease.
机译：维持粘膜稳态的机制对于炎症性肠病至关重要。这些过程的关键是肠上皮细胞（IEC），它调节共生微生物群和宿主之间界面的免疫反应。 CD1d将自身和微生物脂质抗原呈递给自然杀伤性T细胞（NKT），后者参与动物模型和人类炎症性肠病结肠炎的发病机理。

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  • 来源
    《Nature》 |2014年第7501期|497-502|共6页
  • 作者

    Torsten Olszak; Joana F. Neves; C. Marie Dowds; Kristi Baker; Jonathan Glickman; Nicholas O. Davidson; Chyuan-Sheng Lin; Christian Jobin; Stephan Brand; Karl Sotlar; Koichiro Wada; Kazufumi Katayama; Atsushi Nakajima; Hiroyuki Mizuguchi; Kunito Kawasaki; Kazuhiro Nagata; Werner Muller; Scott B. Snapper; Stefan Schreiber; Arthur Kaser; Sebastian Zeissig; Richard S. Blumberg;

  • 作者单位

    Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA;

    Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA;

    Department of Internal Medicine I, University Medical Center Schleswig-Holstein, 24105 Kiel, Germany;

    Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA;

    GI Pathology, Miraca Life Sciences, Newton, Massachusetts 02464, USA;

    Division of Gastroenterology, Washington University School of Medicine, St Louis, Missouri 63110, USA;

    Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA;

    Department of Medicine, Department of Infectious Diseases & Pathology, University of Florida, Gainesville, Florida 32611, USA;

    Department of Medicine Ⅱ-Grosshadern, Ludwig Maximilians University, Munich 81377, Germany;

    Institute of Pathology, Ludwig Maximilians University, Munich 80337, Germany;

    Department of Pharmacology, Graduate School of Dentistry, Osaka University, Osaka 565-0871, Japan;

    Department of Pharmacology, Graduate School of Dentistry, Osaka University, Osaka 565-0871, Japan;

    Gastroenterology Division, Yokohama City University School of Medicine, Yokohama, Kanagawa 236-0027, Japan;

    Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan;

    Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555, Japan;

    Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555, Japan;

    Faculty of Life Sciences, University of Manchester, Manchester M13 9PL, UK;

    Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA,Division of Pediatric Gastroenterology, Hepatology, and Nutrition. Department of Medicine, Children's Hospital Boston, Boston. Massachusetts 02115, USA;

    Department of Internal Medicine I, University Medical Center Schleswig-Holstein, 24105 Kiel, Germany;

    Division of Gastroenterology, Addenbrooke Hospital, University of Cambridge, Cambridge CB2 0QQ, UK;

    Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA,Department of Internal Medicine I, University Medical Center Schleswig-Holstein, 24105 Kiel, Germany;

    Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA;

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  • 入库时间 2022-08-18 02:53:01

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