Effect of phlorotannins from Sargassum thunbergii on blood lipids regulation in mice with high-fat diet

摘要

On the basis of activity screening on blood lipid regulation by animal study, we chose high molecular weight phlorotannins from Sargassum thunbergii (HMPs) as a drug to explore the regulating mechanism. The results showed that HMPs could significantly decrease TC and TG levels (p  0.05), and very significantly decrease LDL-C level (p  0.01). Results of a hypocholesterolemic mechanism study showed that HMPs could obviously increase liver LDL-R level (p  0.05), but the fact that they failed to block the synthesis of HMG-CoA reductase excludes a relevant influence on cellular cholesterol biosynthesis. We propose that HMPs from Sargassum thunbergii have a profound hypocholesterolemic effect and the mechanism relies mainly on the increase of LDL-R level in liver.View full textDownload full textKeywords Sargassum thunbergii , phlorotannins, hypocholesterolemic activity, 3-hydroxy-3-methylglutaryl-coenzyme A, 1ow density lipoprotein receptorRelated var addthis_config = { ui_cobrand: "Taylor & Francis Online", services_compact: "citeulike,netvibes,twitter,technorati,delicious,linkedin,facebook,stumbleupon,digg,google,more", pubid: "ra-4dff56cd6bb1830b" }; Add to shortlist Link Permalink http://dx.doi.org/10.1080/14786419.2011.625500