Genetic polymorphisms of cytochrome p4502E1 and susceptibility to alcoholic liver disease and hepatocellular carcinoma in a white population: a study and literature review, including meta-analysis

摘要

Aims-To investigate the associations be- tween the Rsa I, Dra I, and Taq I genetic polymorphisms of cytochrome p4502E1 and susceptibility to alcoholic liver disease or to hepatocellular carcinoma. Methods- DNA samples isolated from 61 Patients with alcoholic liver disease, 46 Patients with hepatocellular carcinoma, And 375 healthy controls were subjected to Polymerase chain reaction amplification Followed by digestion with the endonucle- Ases Rsa I, Dra I, or Taq I. Meta-analysis Was performed using data from previous Studies of Rsa I polymorphism and the Risk of alcoholic liver disease.