High-Power, Computer-Controlled, Light-Emitting Diode- Based Light Sources for Fluorescence Imaging and Image-Guided Surgery

摘要

Optical imaging requires appropriate light sources. For image-guided surgery, in particular fluorescence-guided surgery, a high fluence rate, a long working distance, computer control, and precise control of wavelength are required. In this article, we describe the development of light-emitting diode (LED)-based light sources that meet these criteria. These light sources are enabled by a compact LED module that includes an integrated linear driver, heat dissipation technology, and real-time temperature monitoring. Measuring only 27 mm wide by 29 mm high and weighing only 14.7 g, each module provides up to 6,500 Ix of white (400-650 nM) light and up to 157 mW of filtered fluorescence excitation light while maintaining an operating temperature ≤ 50℃. We also describe software that can be used to design multimodule light housings and an embedded processor that permits computer control and temperature monitoring. With these tools, we constructed a 76-module, sterilizable, three-wavelength surgical light source capable of providing up to 40,000 Ix of white light, 4.0 mW/cm~2 of 670 nm near-infrared (NIR) fluorescence excitation light, and 14.0 mW/cm~2 of 760 nm NiR fluorescence excitation light over a 15 cm diameter field of view. Using this light source, we demonstrated NIR fluorescence-guided surgery in a large-animal model.