Synthesis and Biodistribution of [11C]Adenosine 5′-Monophosphate ([11C]AMP)

摘要

Imaging purine receptors and adenylate biodistribution in vivo may be of clinical importance not only for the investigation of normal adenylate metabolism but also in pathological conditions where adenylate uptake and/or release from certain tissues and organs may be altered, such as some types of cancer. In order to develop a tracer for positron emission tomography (PET) that would not be subject to loss of its radioisotope, adenosine 5′-monophosphate (AMP) was intrinsically labeled at the C-8 position with carbon-11.