Evaluation of the Integrity of the Dopamine System in a Rodent Model of Parkinson’s Disease: Small Animal Positron Emission Tomography Compared to Behavioral Assessment and Autoradiography

Elissa M. Strome; Ivan L. Cepeda; Vesna Sossi; Doris J. Doudet

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Evaluation of the Integrity of the Dopamine System in a Rodent Model of Parkinson’s Disease: Small Animal Positron Emission Tomography Compared to Behavioral Assessment and Autoradiography

机译：帕金森氏病啮齿动物模型中多巴胺系统的完整性评估：小动物正电子发射断层扫描与行为评估和放射自显影的比较

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摘要

In the 6-hydroxydopamine (6-OHDA) rat model of Parkinson's disease (PD), it is important to determine lesion severity. This evaluation can be performed in vivo, through evaluation of dopamine (DA)-dependent motor function or with small animal positron emission tomography (microPET), or at postmortem, by examining markers for DA neurons.

机译：在帕金森氏病（PD）的6-羟基多巴胺（6-OHDA）大鼠模型中，确定病变的严重程度很重要。可以通过评估依赖多巴胺（DA）的运动功能或使用小型动物正电子发射断层扫描（microPET）进行体内评估，也可以在死后通过检查DA神经元标记来进行评估。

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《Molecular Imaging and Biology》 |2006年第5期|292-299|共8页
作者
Elissa M. Strome; Ivan L. Cepeda; Vesna Sossi; Doris J. Doudet;
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作者单位

Pacific Parkinson’s Research Centre University of British Columbia Purdy Pavilion M36 2221 Wesbrook Mall Vancouver BC V6T 2B5 Canada;

Pacific Parkinson’s Research Centre University of British Columbia Purdy Pavilion M36 2221 Wesbrook Mall Vancouver BC V6T 2B5 Canada;

Pacific Parkinson’s Research Centre University of British Columbia Purdy Pavilion M36 2221 Wesbrook Mall Vancouver BC V6T 2B5 Canada;

Pacific Parkinson’s Research Centre University of British Columbia Purdy Pavilion M36 2221 Wesbrook Mall Vancouver BC V6T 2B5 Canada;

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正文语种 eng
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关键词
MicroPET; Rodent; VMAT2; 11CDTBZ; Dopamine; Striatum; Partial volume effect; 6-OHDA; Behavior; Tapered beam-walking task;

机译：MicroPET;啮齿动物;VMAT2;[11C] DTBZ;多巴胺;纹状体;部分体积效应;6-OHDA;行为;锥形束走任务;

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专利

1. Evaluation of the integrity of the dopamine system in a rodent model of Parkinson's disease: small animal positron emission tomography compared to behavioral assessment and autoradiography. [J] . Strome EM, Cepeda IL, Sossi V, Molecular imaging and biology: MIB : the official publication of the Academy of Molecular Imaging . 2006,第5期

机译：在帕金森氏病啮齿动物模型中评估多巴胺系统的完整性：与行为评估和放射自显影相比，小动物正电子发射断层扫描。
2. Improved dopamine transporter binding activity after bone marrow mesenchymal stem cell transplantation in a rat model of Parkinson's disease: small animal positron emission tomography study with F-18 FP-CIT. [J] . Bok-Nam Park, Jang-Hee Kim, Kwanjae Lee, European radiology . 2015,第5期

机译：改善多巴胺转运蛋白结合活性骨髓间充质干细胞移植在帕金森病大鼠模型中：F-18 FP-CIT小动物正电子发射断层扫描研究。
3. Evaluation of nigrostriatal damage and its change over weeks in a rat model of Parkinson's disease: small animal positron emission tomography studies with ((11)C)beta-CFT. [J] . Liu L, Wang Y, Li B Nuclear Medicine and Biology . 2009,第8期

机译：在帕金森氏病大鼠模型中评估黑质纹状体损害及其在数周内的变化：（（11）C）beta-CFT的小动物正电子发射断层扫描研究。
4. Assessment of natriuretic peptide clearance receptor with positron emission tomography in cardiovascular disease models [C] . Liu Y., Rossin R., Abendschein D., Computers in Cardiology, 2009 . 2009

机译：正电子发射断层扫描在心血管疾病模型中评估利钠肽清除受体的作用
5. Design of an advanced positron emission tomography detector system and algorithms for imaging small animal models of human disease. [D] . Foudray, Angela Marie Klohs. 2009

机译：设计用于对人类疾病的小动物模型进行成像的高级正电子发射断层扫描检测器系统和算法。
6. Performance of Positron Emission Tomography and Positron Emission Tomography/Computed Tomography Using Fluorine-18-Fluorodeoxyglucose for the Diagnosis Staging and Recurrence Assessment of Bone Sarcoma: A Systematic Review and Meta-Analysis: Erratum [O] . -1

机译：使用氟18-氟脱氧葡萄糖对正电子发射断层扫描和正电子发射断层扫描/计算机断层扫描的性能进行的系统评价和荟萃分析：勘误表：骨肉瘤的诊断分期和复发评估
7. MODERATED EPOSTERS1385Longitudinal strain assessment in dilated cardiomyopathy patients using a novel accelerated DENSE sequence1407Simultaneous T1 and T2 cardiac quantification with CABIRIA: initial clinical experience1423Head-to-head comparison of acceleration algorithms in 4-dimensional flow CMR1502Left ventricular function and size evaluated by hybrid cardiac positron emission tomography-magnetic resonance: Intraindividual comparison of left ventricular ejection fraction and ventricular volumes derived by two modalities1510Left Atrium assessed by Cardiovascular Magnetic Resonance at 1.5 and 3 Tesla – age and gender effects1514Comparison of Free Breathing Cardiac MRI Radial technique to the Standard Multi breath-hold cine SSFP CMR technique for the assessment of LV Volumes and Function1536Self-navigated free-breathing isotropic 3D whole heart phase sensitive inversion recovery magnetic resonance without navigator for detection of myocardial infarction1547Assessment of Right Ventricular Strain Using Myocardial Deformation Recovery Semi Automated Technique: Initial Experience and Normal Values1586Tissue tracking myocardial deformation analysis and prediction of left ventricular remodeling in acute myocardial infarction1589Investigating strategies for optimal 31P MRS clinical cardiac at 3T: Initial Results1620Quantitative Criteria for the Diagnosis of the Congenital Absence of Pericardium by Cardiac Magnetic Resonance1632Widespread tissue injury during acute myocardial infarction: evidence from advanced CMR relaxometry1322Computed tomography coronary angiography verSus sTRess cArdiac magneTic rEsonance for the manaGement of sYmptomatic revascularized patients: a cost effectiveness study (STRATEGY study)1339Comparison of low- versus high-dose of gadobutrol for late gadolinium enhancement imaging at 1.5 Tesla: a clinical feasibility study1347Multi-parametric Cardiac Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Intermedia: a Prospective Multicenter Study1461Prognostic value of Cardiovascular Magnetic Resonance derived indexes of myocardial fibrosis in heart transplant recipients1523The role of CMR in the acute phase of hospitalization: changing paradigms1542Preoperative CMR-based score predict ventricular response after surgical left ventricular reconstruction in ischemic heart failure patients1555Excellent response rate to cardiac resynchronization therapy guided with magnetic resonance imaging1626The ECG as a predictor of arrhythmogenic substrate on Cardiac Magnetic Resonance Imaging in patients undergoing ablation for premature ventricular contractions1649Comparison of T1-mapping at 3.0T CMR and angiographic APPROACH score for area at risk assessment in ST-segment elevation myocardial infarction1340Pathological correlates of left bundle branch disease in patients with non-ischemic cardiomyopathy: a cardiovascular magnetic resonance study1342Myocardial remodelling and fibrosis in nonischaemic dilated cardiomyopathy: insights from cardiovascular magnetic resonance1411The association between fibrosis and contractile dysfunction in hypertrophic cardiomyopathy assessed by cardiovascular magnetic resonance1622Persistent myocardial inflammation due to intramyocardial haemorrhage in reperfused STEMI as a precursor to adverse LV remodelling - insights from multi-parametric mapping1566Semiquantitative analysis of low and high b value DWI for detecting myocardial edema in acute myocarditis1567Value of Cardiac MRI In Detecting Coronary Artery Disease In Newly Diagnosed Systolic Dysfunction1570Usefulness of cardiac magnetic resonance in tuberous sclerosis complex1578Papillary muscles offer further insight into hypertrophied hearts: a cardiovascular magnetic resonance study1627Diagnostic and clinical implications of CMR timing (early versus late) in patients with troponin positive acute coronary syndromes and unobstructed coronary arteries: Table 1. [O] . Upasana Tayal, Alexandros Kallifatidis, P. Garg, 2016

机译：在使用新的扩张型心肌病的患者缓和EPOSTERS1385Longitudinal应变评估加速DENSE sequence1407Simultaneous T1和T2与CABIRIA心脏定量：在4维流动的加速算法初始临床experience1423Head对头比较CMR1502Left心室功能和尺寸由混合心脏正电子发射断层摄影术评价 - 磁性共振：由两个modalities1510Left庭派生左室射血分数和心室体积的个体间的比较，在1.5和3特斯拉评估心血管磁共振 - 免费的年龄和性别effects1514Comparison呼吸心脏MRI径向技术标准的多屏气电影SSFP CMR技术的LV卷和Function1536Self-导航自由呼吸各向同性3D整个心脏相位敏感反转恢复磁共振导航仪没有检测右Ventricu心肌infarction1547Assessment的评估拉尔菌株使用心肌变形恢复半自动技术：初步经验和正常Values1586Tissue跟踪心肌变形分析和预测左室重构急性心肌infarction1589Investigating策略优化31P MRS临床心脏在3T：初始Results1620Quantitative标准的先天缺失的诊断心包心脏磁Resonance1632Widespread组织损伤急性心肌梗死时：证据先进CMR relaxometry1322Computed CT冠状动脉成像与压力心脏磁共振对症的管理吻合血管患者：成本效益研究（战略研究）1339Comparison低与高剂量钆布醇在1.5特斯拉晚钆增强成像的临床可行性，在中间型地贫心脏并发症的预测study1347Multi参数心脏核磁共振的前瞻性德穆尔心血管磁共振的ticenter Study1461Prognostic价值衍生心肌纤维化指标在住院的急性期CMR的心脏移植recipients1523The作用：改变基于CMR-paradigms1542Preoperative比分预测缺血性心脏衰竭patients1555Excellent响应速度外科左心室重建心脏再同步化后心室反应治疗与磁共振imaging1626The ECG导引作为心脏磁共振成像致心律失常性基板的在ST段抬高心肌infarction1340Pathological在风险评估经历在3.0T CMR T1映射的室性早搏contractions1649Comparison和血管造影APPROACH分数区域消融患者的预测左束支传导疾病的患者与非缺血性心肌病相关因素：心血管磁共振study1342Myocardial重塑和纤维化nonischaemic扩张型心肌病：在从在由心血管磁性resonance1622Persistent心肌炎症评估肥厚型心肌病的纤维化和收缩功能障碍之间心血管磁性resonance1411The协会由于心肌内出血景点在再灌注STEMI为先导，以不利的LV重塑 - 从低的多参数mapping1566Semiquantitative分析和高的b值DWI的见解为在心脏MRI检测冠状动脉疾病急性myocarditis1567Value在结节性硬化症complex1578Papillary肌肉初诊收缩期Dysfunction1570Usefulness心脏磁共振检测心肌水肿提供进一步的深入了解肥大心脏：心血管磁共振study1627Diagnostic和CMR定时的临床意义（早期与晚）患者肌钙蛋白阳性的急性冠脉综合征和通畅的冠状动脉：表1。
8. Impact of Exercise on the Vulnerability of Dopamine Neurons to Cell Death in Animal Models of Parkinson's Disease [R] . Zigmond, M. J., Smith, A., Liou, A. 2008

机译：运动对帕金森病动物模型中多巴胺神经元易损性细胞死亡的影响

Evaluation of the Integrity of the Dopamine System in a Rodent Model of Parkinson’s Disease: Small Animal Positron Emission Tomography Compared to Behavioral Assessment and Autoradiography

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