Replacing 99mTc with 111In Improves MORF/cMORF Pretargeting by Reducing Intestinal Accumulation

Guozheng Liu; Dengfeng Cheng; Shuping Dou; Xiangji Chen; Minmin Liang; P. Hendrik Pretorius; Mary Rusckowski; Donald J. Hnatowich

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Replacing 99mTc with 111In Improves MORF/cMORF Pretargeting by Reducing Intestinal Accumulation

机译：用111 In代替99m Tc可通过减少肠道积累来提高MORF / cMORF的靶向性

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摘要

To reduce accumulation in the abdomen by MORF/cMORF pretargeting, 111In was compared to 99mTc as the radiolabel.

机译：为了通过MORF / cMORF预靶向减少腹部积累，将111 In与99m Tc作为放射性标记进行了比较。

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来源
《Molecular Imaging and Biology》 |2009年第5期|303-307|共5页
作者
Guozheng Liu; Dengfeng Cheng; Shuping Dou; Xiangji Chen; Minmin Liang; P. Hendrik Pretorius; Mary Rusckowski; Donald J. Hnatowich;
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作者单位

Division of Nuclear Medicine Department of Radiology University of Massachusetts Medical School 55 Lake Ave North Worcester MA 01655-0243 USA;

Division of Nuclear Medicine Department of Radiology University of Massachusetts Medical School 55 Lake Ave North Worcester MA 01655-0243 USA;

Division of Nuclear Medicine Department of Radiology University of Massachusetts Medical School 55 Lake Ave North Worcester MA 01655-0243 USA;

Division of Nuclear Medicine Department of Radiology University of Massachusetts Medical School 55 Lake Ave North Worcester MA 01655-0243 USA;

Division of Nuclear Medicine Department of Radiology University of Massachusetts Medical School 55 Lake Ave North Worcester MA 01655-0243 USA;

Division of Nuclear Medicine Department of Radiology University of Massachusetts Medical School 55 Lake Ave North Worcester MA 01655-0243 USA;

Division of Nuclear Medicine Department of Radiology University of Massachusetts Medical School 55 Lake Ave North Worcester MA 01655-0243 USA;

Division of Nuclear Medicine Department of Radiology University of Massachusetts Medical School 55 Lake Ave North Worcester MA 01655-0243 USA;

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原文格式 PDF
正文语种 eng
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关键词
Pretargeting; Anticancer; Antibodies; Tumor; Radioimmunotargeting;

机译：预靶向;抗癌;抗体;肿瘤;放射免疫靶向;

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专利

1. Replacing 99mTc with 111In improves MORF/cMORF pretargeting by reducing intestinal accumulation. [J] . Liu G, Cheng D, Dou S Molecular imaging and biology: MIB : the official publication of the Academy of Molecular Imaging . 2009,第5期

机译：用111In替代99mTc可通过减少肠道积累来改善MORF / cMORF的靶向性。
2. Human Islet Cell MORF/cMORF Pretargeting in a Xenogeneic Murine Transplant Model. [J] . Liu G, Dou S, Cheng D, Molecular pharmaceutics . 2011,第3期

机译：人胰岛细胞MORF / cMORF在异种鼠移植模型中的预靶向。
3. A preclinical (188) Re tumor therapeutic investigation using MORF/cMORF pretargeting and an antiTAG-72 antibody CC49. [J] . Liu G, Dou S, Baker S, Cancer biology & therapy . 2010,第8期

机译：使用MORF / cMORF预靶向和抗TAG-72抗体CC49的临床前（188）肿瘤治疗研究。
4. Improved production of 1,3-propanediol in engineered Escherichia coli by reducing accumulation of toxic intermediates. [D] . Zhu, Meiying. 1999

机译：通过减少有毒中间体的积累，改善了工程化大肠杆菌中1,3-丙二醇的生产。
5. Replacing 99mTc with 111In improves MORF/cMORF pretargeting by reducing intestinal accumulation [O] . Guozheng Liu, Dengfeng Cheng, Shuping Dou, -1

机译：用111英寸更换99MTC通过减少肠累积来改善Morf / Cmorf预靶向
6. Human Islet Cell MORF/cMORF Pretargeting in a Xenogeneic Murine Transplant Model [O] . Guozheng Liu, Shuping Dou, Dengfeng Cheng, 2011

机译：人体胰岛细胞Morf / Cmorf在异种鼠移植模型中预靶

Replacing 99mTc with 111In Improves MORF/cMORF Pretargeting by Reducing Intestinal Accumulation

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