Enantioselective Addition of Organozinc to Aldehydes and Ketones Catalyzed by Immobilized Chiral Ligands

摘要

Catalytic enantioselective addition of organozinc reagents to carbonyl groups is a valuable method for the synthesis of optica-nlly active alcohols. Such asymmetric organozinc additions allow the synthesis of chiral alcohols ubiquitous in the structures of natural nand manmade compounds. Recent interest in green chemistry has led to active research in the immobilization of catalysts, and their ap-nplication to asymmetric reactions. Besides simplifying compound separation and recycling, immobilized catalysts offer easier handling of ntoxic reagents, and convenient operation in continuous flow reactors. Thus, industrial applications of even expensive and complex chiral ncatalysts can be achieved in an economical and environmentally benign way.