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Dielectrophoretic 3D-focusing for on-chip flow cytometry

机译:用于片上流式细胞仪的介电泳3D聚焦

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摘要

Model-based analysis of a dielectrophoretic microfluidic device for realising 3D-focusing is presented in this work. The electrode configuration is made up of several finite-sized planar electrodes positioned on either side of the microchannel's top and bottom surfaces; the electrodes on the top surface and bottom surface of the same side form a pair. The forces associated with inertia, buoyancy, gravity, and dielectrophoresis are included in the model. As per the model, it is possible to use the proposed device to achieve 3D-focusing at the desired location along the width of the microchannel. Also, the proposed device can achieve 3D-focusing irrespective of the type of micro-scale entity. Two parameters for quantifying the efficacy of the microfluidic device in achieving 3D-focusing are presented - horizontal and vertical focusing parameters. The model demonstrates that the radius of micro-scale entity, electrode/gap lengths, electrode width, microchannel height, number of electrodes, applied electric potentials, and volumetric flow rate influence horizontal and vertical focusing parameters. The mathematical model is thus useful in designing dielectrophoresis-based 3D-focusing with desired performance metrics for on-chip flow cytometry.
机译:在这项工作中提出了一种基于模型的介电泳微流体装置来实现3D聚焦的微流体装置。电极配置由位于微通道顶部和底表面的任一侧的几个有限大小的平面电极组成;相同侧面的顶表面和底表面上的电极形成一对。与惯性,浮力,重力和介电电泳相关的力包括在模型中。根据该模型,可以使用所提出的装置在沿着微通道的宽度实现在所需位置的3D聚焦。而且,该装置可以实现3D聚焦,而不管微尺度实体的类型。提供了用于量化微流体装置在实现3D聚焦方面实现3D聚焦的功效的两个参数 - 水平和垂直聚焦参数。该模型演示了微尺度实体,电极/间隙长度,电极宽度,微通道高度,电极数,施加的电位数和体积流量影响水平和垂直聚焦参数的半径。因此,数学模型可用于设计基于介电泳的3D聚焦,具有用于片上流式细胞仪的所需性能度量。

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  • 来源
    《Micro & nano letters》 |2020年第5期|296-301|共6页
  • 作者单位

    United Arab Emirates Univ Dept Mech Engn Abu Dhabi U Arab Emirates;

    United Arab Emirates Univ Dept Mech Engn Abu Dhabi U Arab Emirates;

    Abu Dhabi Polytech Abu Dhabi U Arab Emirates;

    Jordan Univ Sci & Technol Dept Mech Engn Irbid Jordan;

    United Arab Emirates Univ Dept Mech Engn Abu Dhabi U Arab Emirates;

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  • 正文语种 eng
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