X-ray Diffraction and Thermal Characterization Study of Sm~Ⅲ Complex of Sulphonylurea, Glipizide: An Oral Antidiabetic Drug

摘要

The present paper deals with the study of sulphonylurea glipizide (GLP) drug in order to give a thought concerning its coordinating potentiality towards some inner transition metals. Metal complex of GLP drug is synthesized and characterized by using analytical data, molar conductance, X-ray diffraction and thermogravimetric analysis (TGA) studies. From the analytical data, the complex is proposed to have general formula(C_(21)H_(26)N_5O_4S)_2Sm(OH_2)_4.Low values of molar conductance indicate that complex have non ionic nature. The conductometric titration using monovariation method reveal that complex is L_2M type which is further confirmed by Job's method of continuous variation as modified by Turner and Anderson. Geometery of complex is assigned to be hexagonal in which ligand molecules lie horizontally joining the central metal atom and four water molecules attached vertically and horizontally with the metal, supported by spectroscopic study. Powder X-ray diffraction data have been used to calculate particle size, porosity, volume of unit cell and density of synthesized complex.The thermal decomposition of complex is studied using thermogravimetric (TGA) techniques. The kinetic parameters such as, energy of activation (E_a), enthalpy (ΔH), entropy (ΔS) and free energy change (ΔG) of the complexis evaluated by employing the Freeman-Carroll and Sharp-Wentworth methodsand the relative thermal stability of the complexisalso discussed.