Synthesis, Spectral Characterization and X-ray Diffraction Studies of Cerium Complex of Glipizide, An Oral Antidiabetic Drug

摘要

Glipizide is a second generation sulphonylurea with promising hypoglycemic activity. It acts by stimulating the release of insulin from β-cells of pancreas. The present paper describes the synthesis and characterization of cerium complex with Glipizide. The conductometric titration using monovariation method reveal that complex is non-ionic and ML, type which was further confirmed by Job's method of continuous variation as modified by Turner and Anderson. The analytical data agree with the molecular formula (C_(21)H_(26)N5O4S)2Ce(OH2)2, that the structure of complex was assigned as octahedral in which ligand molecules lies horizontally joining the central cerium atom. IR, NMR confirms the co-ordination of sulphonyl oxygen on one side and enolic oxygen attached from other side with the metal ion.The structure of complex was proposed on the basis of analytical data, elemental analysis, IR, ~1H NMR and X-ray Diffraction studies.