Engineering pharmaceutical nanocarriers for photodynamic therapy on wound healing: Review

摘要

In the present scenario, promising efforts have been improved by the researchers towards the development of nanocarriers that can be challenge fundamental tasks in photodynamic therapy (PDT) for wound management. In the past few years, nanotechnology-based therapy has attracted good attention with the advancement of nanotechnology such as PDT, chemotherapy, photothermal therapy. PDT has emerged as a promising clinical treatment method for wound healing. In this respect, great effort has been made towards the development of nanocarriers for targeted PDT in wound management. Nowadays, attention is concentrated on the advancement of nanomaterials using innovative methods in wound care for treating wounds with the faster healing effect. In this review, we present and discuss how nanocarriers have arisen as an interesting delivery nanoplatform for effective and consistent PDT. They can be easily delivered photodynamically and can demonstrate healing mechanisms for achieving target wound tissue/cells; therefore, PDT can be used in wound treatment to target cells specifically through release on demand, target-specific delivery, and in vivo labelling imaging. In addition, we also highlighted that the future goal for researchers is the development of biocompatible and biodegradable nanomaterials for all the phases of wound healing.